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KMID : 0356820150310020011
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Korean Journal of Head & Neck Oncology
2015 Volume.31 No. 2 p.11 ~ p.15
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Clinical Manifestations of Papillary Thyroid Carcinoma Recurred as Distant Metastases
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Kim Nam-Young
Kim Kyoung-Hun
Park Sung-Ho
Lee Guk-Haeng
Lee Byeong-Cheol
Lee Myung-Chul
Choi Ik-Jun
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Abstract
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Background and Objectives: This study aimed to analyze the features of patients with papillary thyroid carcinoma (PTC) recurred as distant metastases (DM).
Materials and Method: We retrospectively reviewed and analyzed clinical records of 63 patients who were treated for PTC recurred as DM between 2000 and 2006. Univariate and multivariate analyses of various clinical factors were performed.
Results: Male patients were 12, and female patients were 51. The 5- and 10-year survival rates for PTC recurred as DM were 85% and 73%, respectively. Size of tumor, multiplicity of tumor, lateral neck node metastasis, and RAI ablation therapy with other treatments such as surgery were associated with survival rate (p < 0.005) in univariate analysis. The lateral neck node metastasis[p =0.039, hazard ratio=2.2(95% CI. 1.18~3.24)] and multiple organ DM[p =0.041, hazard ratio=2.18(95% CI. 1.03~2.89)] were related to the survival in multivariate analysis.
Conclusion: PTC recurred as DM is uncommon (2.2%). The size of tumor, the multiplicity of tumor, lateral neck node metastasis and RAI ablation therapy with other treatments for DM were revealed as associated factors for the survival. Evaluation of DM should be considered in patients with PTC during long-term follow-up.
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KEYWORD
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Thyroid Papillary Carcinoma, Distant Metastases
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